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CUSTOMER SPOTLIGHTS
University of Manitoba - Researchers Look for Answers to Colorectal Cancer
 
Featuring: Cytation 3
 
ManitobaLike many researchers, Dr. Kirk McManus, Associate Professor in the Department of Biochemistry and Medical Genetics at the University of Manitoba, has many questions, and he and his team are very busy, looking for answers! The main goals of Dr. McManus' primary research area, colorectal cancer, are to a) identify aberrant genes that cause chromosome instability (CIN), and b) once these genes are found, identify new drug targets that exploit the aberrant genes through synthetic lethality. Using a well-known YouTube video as a simple analogy, Dr. McManus explains that his group is looking for the "Mentos that cause the aberrant 'gene' in Diet Coke to erupt".  Although they work primarily with colorectal cancer models, the results of their experiments are applicable to other tumors, since CIN is also seen in other solid and liquid cancers.
 
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FEATURED APPLICATION
 
Utility of Variable Bandwidth Monochromators for Quantification of Fluorescent Probes in Produced Effluent Water
 
Featuring: Synergy Neo2
 
One of the primary waste products during the separation of oil, gas and water is produced effluent water, which is typically a mixture of formation and injection process water containing oil, salts, chemicals, solids and trace metals. Monitoring of oil content in water streams from oil production and refining is critical to meet stringent regulations for returning produced water to the environment, and is regulated by the Environmental Protection Agency (EPA) in the US. As the current trend is to further reduce the level of crude oil released in produced water streams, more advanced methods are necessary to accurately detect minute traces of oil in purified samples; many times reaching the parts per million (ppm) or parts per billion (ppb) level.
 
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TEK CORNER
 
Sample Preparation for Fluorescence Microscopy: An Introduction - Concepts and Tips for Better Fixed Sample Imaging Results
 
Featuring: Cytation 5, Cytation 3
 
Multiple processing steps are required to prepare tissue culture cells for fluorescence microscopy. Experiments are generally classified as being either live or fixed cell microscopy. Fluorescence microscopy of live cells uses either genetically encoded fluorescent proteins (e.g. GFP, mcherry, YFP, RFP, etc.) or cell membrane-permeable, non-toxic fluorescent stains. Fluorescence microscopy of fixed cells uses a fixative agent that renders the cells dead, but maintains cellular structure, allowing the use of specific antibodies and dyes to investigate cell morphology and structure. Appropriate sample preparation is necessary to ensure high quality images are captured.
 
 
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PRODUCT SPOTLIGHT
BioTek's New Synergy Neo2 Raises the Bar for Multi-Mode Detection Performance
 
Synergy Neo2The Synergy™ Neo2 is designed for speed, performance and functionality. BioTek's patented Hybrid Technology™, with its independent optical paths that ensure uncompromised performance in all detection modes. Multiple PMTs, including dual top PMTs for ultrafast ratiometric measurements like FP, FRET and TR-FRET, with excellent results. For live cell assays, Synergy Neo2 has advanced environment controls, including incubation to 65 °C, shaking and CO2/O2 control and monitoring. Cell-based assay detection uses direct bottom illumination for optimal results. The continuously variable bandwidth quad monochromators ensure accurate measurements of many fluorophores, including those with small Stokes' shifts and multiplex assays. Synergy Neo is controlled by Gen5 software, with Gen5 Secure available for laboratories that require 21 CFR Part 11 compliance.
 
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TEK TIPS
BioTek's Cytation, Synergy and Epoch readers can read commonly used Petri and cell culture dishes, using the appropriate adapters for 35, 60 and 100 mm dishes
The plate database in Gen5 software includes several types of dishes, so it's simple to select the correct dish when creating the read protocol. The well area scan read mode allows the plate reader to measure several points in a matrix across the large wells and reports back the results from each data point and the average measurement from each well.
 
How many BioTek readers and washers/dispensers can run in parallel within a third party automated system?
With Gen5 and LHC software, there is virtually no limit on the number of instruments that can be connected and run in parallel. Users should just be sure the controlling PC is equipped with sufficient memory.
 
Do you want to use a house vacuum for your washer applications?
Our Vacuum Regulator Kit, PN 4030551 has recently been updated, including the addition of hardware improvements and instructions. Our desire was to provide our customers with more detailed information. The new instructions clearly show how to properly setup the regulator, and what the maximum vacuum levels should be. The Vacuum Regulator Kit can be used with 405 Touch Washer, 405 LS Washer, EL406 Washer Dispenser and ELx405 Select Deep Well Washer.
FEATURED VIDEOS
Neo2 Video
BioTek's Synergy Neo2 is the most advanced high-performance, high-speed plate reader on the market today.
EL406 video
BioTek's EL406 automates the entire cell preparation process.
Biocompare Bench Tip Video
A discussion on 3D Cell Culture and the impact it has had on advancing drug discovery research.
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