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Ptk2 cells (rat kidney) at 20x, image taken on Cytation 3 Cell Imaging Multi-Mode Reader. Cells fixed and stained for tubulin (green), actin (red) and nucleic (blue).

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CUSTOMER SPOTLIGHTS

A New, Automated Path to Ask More Complicated Questions and Receive Enhanced Answers
Dr. Sachin Katyal, University of Manitoba and CancerCare Manitoba
Related ProductsGen5Cytation 5EL406

Sachin K.
With more than a decade of experience, few researchers have more expertise than Dr. Sachin Katyal when it comes to the comet assay, also known as single cell gel electrophoresis (SCGE). As a post-doc at St. Jude Children’s Research Hospital, Dr. Katyal incorporated this assay to study neural damage, and now in his dual role as Assistant Professor in Pharmacology and Therapeutics at the University of Manitoba and Senior Scientist with the Research Institute in Oncology and Hematology (RIOH) at CancerCare Manitoba in Winnipeg, Canada, Dr. Katyal applies the comet assay in his studies on brain tumors and other cancers.

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A Simple Yet Powerful Method for Measuring Real-Time Kinase Activity
AssayQuant Technologies, Inc.
Related Product: Synergy Neo2, BioStack
 Dr. Erik Schaefer discussing latest results with Susan Cornell-Kennon, Senior Research Scientist at AssayQuant, with results using PhosphoSens™ technology displayed in real time.

AssayQuant Technologies, Inc., in Marlborough, Massachusetts is a growing Life Science company that develops innovative enzyme assay formats for a quantum improvement in performance and productivity to enable discovery or accelerate drug development. Its founders, Dr. Erik Schaefer and Dr. Barbara Imperiali, each impart a wealth of experience that allows AssayQuant to deliver exceptional value to their customers.

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UPCOMING WEBINAR

"Enabling Quantitative Cellular Imaging"
Presenter: Brad Larson, Principal Scientist, BioTek Instruments

In this webinar we will demonstrate how robust quantitative image-based results for cell biology can be achieved through automated digital microscopy and image analysis techniques under both fixed and live cell conditions.

Wednesday, November 16, 2016
12:00 - 1:00 PM EST

FEATURED APPLICATION

 

Automated Comet Assay Imaging and Dual-Mask Analysis to Determine DNA Damage on an Individual Comet Basis

Mammalian cells incur DNA damage and alterations as a result of internal factors, such as stress, environment, oxidation and metabolism, as well as exposure to external stimuli, such as chemical compounds, UV and cosmic radiation. Genotoxicity studies aim to identify and understand the mechanisms of DNA damage and repair, and also to seek methods of pathway regulation and dysregulation for improved therapeutic success. Beyond therapeutic implications, a number of industries, including cosmetics, food/beverage, chemical and mining/ oil/petroleum, incorporate genotoxicity testing to characterize the safety profile of their products.
 
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TEK CORNER

 

Automated Cell Image Analysis for Verification of Cell Retention during Vigorous Cell Washing
Comparison of Automated and Manual Cell Washing and Automated Cell Counting and Cell Confluency Analysis

Automated workflows have gained in popularity with the increased adoption rate of cell based assays performed in higher density microplate formats. Increased throughput and reproducibility are best achieved when processes such as media exchanges and cell washing are automated in conjunction with reagent additions. Microplate instrumentation has become more complex, as has assay development. Liquid handlers now offer a wide variety of available fluid pathway combinations and detection instruments combine traditional detection channels with microscopy capabilities. Automated workflows can be designed to offer walk-away solutions with increased performance when compared to manual methods.

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PRODUCT SPOTLIGHT

Automated Live Cell Imaging & AnalysisLionheart FX

The BioSpa Live Cell Imaging System brings together BioSpa Automated Incubator and Cytation 5 Cell Imaging Multi-Mode Reader to fully automate live cell imaging and analysis workflows. Cytation 5 provides high quality, powerful data-rich image capture, processing and analysis of live cell assays, up to 60x. BioSpa's temperature, gas and humidity controlled environment houses and protects cells in up to 8 microplates or other labware. The robotic gripper moves the plate from the incubator drawers to Cytation 5 for kinetic imaging and analysis in Gen5 software. Plate washing and reagent dispensing can be added to the system, for complete automation from sample prep through image analysis.  BioSpa’s software seamlessly integrates imaging and liquid handling protocols in an easy scheduling interface - reporting and 24/7 monitoring of all processes.

TEK TIPS

 Absorbance Testing at 340 nm – no liquids required! 

Test plateThe new 340 nm Absorbance Test Plate (PN 7260551) makes measuring  absorbance performance of your BioTek microplate reader at 340 nm fast and easy, with no liquid tests required!  This new 340 nm Absorbance Test Plate, along with BioTek’s standard Absorbance Test Plate (PN 7260522E) help your laboratory test critical performance specifications including alignment, accuracy, reproducibility and linearity at a wide range of wavelengths.  Find out more about how you can streamline and simplify your BioTek microplate reader performance  at 340 nm here.

 Gen5 Image Analysis Tip: View Multiple Wells Simultaneously
When optimizing image analysis parameters it is good practice to use images from multiple conditions such as negative and positive controls. Gen5 allows users to view multiple images simultaneously to easily compare how analysis settings are applied across a dataset. You can toggle the display of images from tabbed pages to individual windows by clicking the Gen5 icon icon in the upper right corner of the Analyze Tool window. Viewing images side-by-side helps to ensure a robust analysis across the range of conditions represented in your experiment.

 View our FAQ's on www.biotek.com.
Our Frequently Asked Questions database is loaded with useful tips and answers to some of the most common questions about our products.

FEATURED VIDEOS

Think Possible

  Lionheart FX Automated Live Cell Imager
When you think of the future, what do you think is possible? At BioTek we're constantly innovating to provide Scientists with state of the art instrumentation to help them in the discovery process...

The Switch to MultiFlo FX

Live cell Assay Automation
See how switching to the MultiFlo FX dispenser from BioTek can streamline your workflow and improve efficiency.
NEW APPLICATION NOTES
http://www.biotek.com/resources/             
  Lionheart FX Automated Live Cell Imager Debuts at Experimental Biology 2016
Live cell Assay Automation

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